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CD4mc Sensitizes HIV-1 Infected Macrophages to Antibody-Dependent Cellular Cytotoxicity
Description
CD4-mimetic compounds (CD4mc) induce conformational changes in HIV-1 Env, exposing otherwise hidden CD4-induced epitopes. This sensitizes infected macrophages to ADCC by promoting vulnerable Env conformations, demonstrating the potential of CD4mc in enhancing immune responses against HIV-1.
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