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ER+ Cancer Treatment Complexity NLRP3, TP53 Loss, Aromatase Excess, and Neuroinflammation
Creator
s
Description
In aromatase excess, adipose tissue converts androgens to estradiol (E₂), amplified by DHEA. E₂ activates NLRP3 via ERα on mast cells. GLP-1 agonists lower E₂, Xolair blocks degranulation, and dipyridamole inhibits NEK7-NLRP3 coupling and mitochondrial ROS. LDN blocks TLR4 priming; Ilaris neutralizes IL-1β. Together these reduce M1 polarization and cytokine-driven epithelial proliferation, especially in TP53-mutant tissue. Metformin suppresses ERα signaling and E₂ synthesis.
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