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Impact of Glucocorticoid Levels on Metabolism and Cardiac Function
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Description
Glucocorticoid deficiency leads to reduced body fat, heightened energy expenditure, and low lipid levels due to impaired cortisol production. Excessive glucocorticoids inhibit 17-OHP metabolism, triggering glucocorticoid receptor activation and high blood sugar via increased hepatic glucose production and insulin resistance. Additionally, this deficiency reduces cardiac output and the catecholamine pressor effect.
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