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Leptin Stimulates Synaptogenesis in Hippocampal Neurons via KLF4 and SOCS3
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
In developing hippocampal neurons, leptin induces maturation of spines, main sites of excitatory synapses. In non-treated neurons, high levels of signal transducer and activator of transcription 3 (STAT3) negatively regulates synapse formation causing less mature spines and excitatory postsynaptic currents. Leptin addition increases expression of Kruppel-Like Factor 4 (KLF4) and suppressor of cytokine signaling 3 (SOCS3), which inhibit STAT3, resulting in enhancement of glutamatergic synapses.
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