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miR-17~92 suppresses cervical cancer progression by inhibiting cell cycle regulator Cdt2
Creator
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Description
miR-17~92 suppresses mRNA of Cdt2 via miRNA induced silencing, leading to inhibition of Cdt2 protein production. Suppression of Cdt2 protein eventually leads to stabilization of a replication licensing factor Set8 causing S phase arrest in the cancerous cells. This in turn leads to inhibition of proliferation, invasion and migration abilities of the cervical cancer cells
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