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Nicotine action in non small lung cancer cells
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Description
Nicotine binds to NAChRs implicating many signaling cascades. PI3-K pathway activated XIAP ubiquitination prevented. ERF protein disassociates from Rb translocates into nucleus and upregulates survivin. XIAP survivin inhibit apoptosis. PARP cleavage inhibited, DNA repair prevented. P53 dissociation from MDM2 inhibited, P21 transcription prevented, cell arrest cannot occur cells continues to divide.
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