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Nucleic acid sensing in ANCA-associated vasculitis
Creator
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Description
Activation and subsequent extravasation of neutrophils and the release DNA in the extracellular space can induce an immune reaction where DNA:antibody - immune complexes can be translocated/uptaken by monocyte-derived macrophages. Nucleic acid sensors like cGAS, were shown to sense this DNA and trigger an immune response by producing pathogenic type-I. Interferon (IFN). This in turn, was shown to damage the endothelial cell barrier and to induce pulmonary hemorrhages.
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