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BioRender Template
Schematic representation of cellular interactions in the growth plate environment
Creator
s
Description
The diagram shows chondrocyte stages from resting (RCs) to proliferative (PCs), prehypertrophic (PHCs), hypertrophic (HCs), and terminal hypertrophic (THCs). Key signaling pathways, including PTHrP, Ihh, VEGF, IGF1, RANKL, BMP, and FGF18, are indicated with arrows. Interactions between chondrocytes and surrounding cells (osteoblasts, osteoclasts, and vascular endothelial cells) highlight IGF1, FGF23, and Wnt signaling in growth plate regulation, with feedback inhibition SOST also shown.
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