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BioRender Template
Sonic Hedgehog Signaling
Creator
s
Description
In the absence of sonic hedgehog (Shh), the patched (Ptch) inhibits smoothened receptor (Smo) allowing Supressor of Fused (SUFU) to bind and inhibit Gli1. When Shh binds Ptch, Ptch's inhibition of Smo ceases, allowing Smo to inhibit SUFU freeing up Gli1 which can then enter the nucleus and regulate target gene expression.
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