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BioRender Template
The diagram of the inhibition of TSLP Signaling by HZ-1127 and TEZE
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Description
The left panel depicts the canonical TSLP signaling pathway initiated by TSLP binding to its receptor complex, consisting of TSLPR and IL-7Rα on the cell surface. This interaction activates the JAK1/JAK2 pathway, leading to the phosphorylation and nuclear translocation of STAT5 and STAT3, which ultimately results in cytokine gene expression and subsequent inflammatory response. Right panel demonstrates the inhibitory action of HZ-1127, and TEZE as a positive control, on TSLP signaling.
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