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2-Deoxy-D-Glucose (2-DG) effects on endoplasmic reticulum (ER) stress
Creator
s
Description
Gene expression increases the mRNA that is translocated to the ER lumen. In the lumen, the N-glycan is added to the protein, and is recognized by the CNX/CRT cycle. If the glycoprotein has the proper structure, it is transported outside of the ER to Golgi. If the glycoprotein did not acquire the proper structure, the ERAD pathway is activated. 2-DG truncates the formation of the N-glycans, leading to altered N-glycosylation that prevents the proper folding of glycoproteins.
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