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BioRender Template
A Diagram of the P53 Apoptosis pathway
Creator
s
Description
DNA damage activates DNA-dependent kinases, which phosphorylate p53, leading to its activation. Active p53 elevates P21 levels, causing G1 phase arrest. If repair fails, apoptosis ensues, as p53 boosts Bax transcription. Bax-Bcl2 complexes cannot seal mitochondrial pores, enabling cytochrome-c release. Cytochrome-c binds Apaf-1, initiating apoptosome formation with caspase-9 and activating apoptosis cascades with other caspases.
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