BioRender Template

A general model illustrating p97/VCP mechanism of action

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Aryatara Shakya

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Description: p97, aided by ubiquitin-binding cofactors (E1, E2, E3), remodels ubiquitinated substrates through ATP hydrolysis, facilitating their segregation from cellular structures. Interactions with ubiquitin-editing enzymes, like E4 chain extension factors or deubiquitinating enzymes (DUBs), further regulate substrate fate, influencing either degradation or recycling pathways.

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What does the A general model illustrating p97/VCP mechanism of action template show?

p97, aided by ubiquitin-binding cofactors (E1, E2, E3), remodels ubiquitinated substrates through ATP hydrolysis, facilitating their segregation from cellular structures. Interactions with ubiquitin-editing enzymes, like E4 chain extension factors or deubiquitinating enzymes (DUBs), further regulate substrate fate, influencing either degradation or recycling pathways.

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