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BioRender Template
α-Synuclein Degradation and Accumulation Pathways
Description
This template shows how alpha-synuclein is normally cleared through the lysosomal autophagy and proteasome-ubiquitin systems, while mitochondrial abnormalities from mutations in LRRK2, DJ-1, PINK1, and Parkin drive oxidative stress and neuroinflammation. When clearance fails, alpha-synuclein misfolds into toxic oligomers, beta-pleated sheets, and ultimately Lewy bodies.
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