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Abbreviated Cellular Mechanisms of Hyperalgesia
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Description
In response to tissue damage, nociceptors release a series of cellular factors including substance P, calcitonin gene-related protein (CGRP), and ATP. These factors induce a series of additional effects by acting on blood vessels, mast cells, and macrophages. Stimulated substrates (histamine, IL-1beta, TNF-alpha) and ATP can in turn act on nociceptors to sensitize (+) these free nerve endings. This sensitization is the cellular underpinnings of hyperalgesia.
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