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Aberrant Splicing of Mesenchymal Epithelial Transition (MET) gene

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Samara Ona

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BioRender Team

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Description: This template shows aberrant splicing of the MET gene in which a splicing error causes exon 14 skipping, producing an mRNA transcript missing exon 14 and a truncated but signaling-competent MET protein. Because CBL can no longer bind and ubiquitinate the altered receptor, the protein escapes degradation, leading to increased protein levels and upregulated signaling.

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What does the Aberrant Splicing of Mesenchymal Epithelial Transition (MET) gene template show?

This template shows aberrant splicing of the MET gene in which a splicing error causes exon 14 skipping, producing an mRNA transcript missing exon 14 and a truncated but signaling-competent MET protein. Because CBL can no longer bind and ubiquitinate the altered receptor, the protein escapes degradation, leading to increased protein levels and upregulated signaling.

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