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AChRA mechanisms of action

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Mariana Bendersky

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Description: a-b) The C1q component of complement binds to the AChRA-receptor complex, leading to the destruction of the post-synaptic membrane c) AChRAs have divalent functionality, i.e. they can bind to two different AChR molecules, this causes accelerated internalization and degradation of receptors d) Antibodies bind to the α subunit (MIR) and interfere with the binding of ACh molecules

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a-b) The C1q component of complement binds to the AChRA-receptor complex, leading to the destruction of the post-synaptic membrane c) AChRAs have divalent functionality, i.e. they can bind to two different AChR molecules, this causes accelerated internalization and degradation of receptors d) Antibodies bind to the α subunit (MIR) and interfere with the binding of ACh molecules

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