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BioRender Template
Activation of B-cells
Creator
s
Description
Three signals are required for the activation of B-cells. Signal 1 is the recognition of an antigenic epitope by the B-cell receptor (BCR). Signal 2 is comprised of intermolecular interactions between surface molecules present on the B-cell (namely CD40, MHC and B7) and the antigen-specific T-helper cell (CD40L, TCR and CD28). Signal 3 is comprised of the costimulatory cytokine released from the T-helper cell and which binds to the cytokine receptor present on the B-cell.
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