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Activation of Protein Kinase C (PKC)
Description
This template shows activation of protein kinase C (PKC) starting from ligand binding to a GPCR, which activates PLC to cleave PIP2 into DAG and IP3. IP3 triggers calcium release from the ER while DAG activates PKC at the membrane, and both calcium binding proteins and PKC phosphorylation converge to produce a cellular response.
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