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Adverse Effects of Chronically Elevated Cortisol Levels on Target Tissues
Description
The systemic consequences of sustained cortisol elevation across multiple organs. Chronic cortisol excess promotes skeletal muscle atrophy, neurodegeneration and cognitive impairment in the brain, insulin resistance and inflammation in adipose tissue, hepatic steatosis and dysfunction in the liver, and vascular complications such as endothelial dysfunction. These widespread effects underscore the critical importance of regulating cortisol levels to maintain metabolic health.
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