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BioRender Template
Alphavirus Infection Cycle
Creator
s
Description
Virions bind attachment factors (e.g., HS) or receptors (e.g., MXRA8, LDLRAD3) and enter via clathrin-mediated endocytosis. Acidic endosomes induce envelope changes for membrane fusion and cytoplasmic entry. Genomic RNA translation yields polyproteins P123 and P1234, processed by nsP2 protease into replicase complexes for RNA synthesis. Structural proteins mature in the ER/Golgi, and nucleocapsid assembly triggers virion budding and egress.
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