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Androgen Receptor-Mediated Mechanisms of Castration Resistance in Prostate Cancer and Therapies
Description
This template shows seven mechanisms (A-G) of androgen receptor-mediated castration resistance in prostate cancer, including aberrant AR activation by growth factors, intratumoral steroid synthesis, AR splicing variants, AR promiscuity, coregulator modification, AR amplification, and post-translational modification, all converging on AR target gene transcription and increased growth and survival. Corresponding therapies are labeled in blue at each node, such as abiraterone, enzalutamide, docetaxel, and finasteride.
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