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Angiotensin converting enzyme (ACE) degradation of Substance P (SP)

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Aria Walls

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Description: Angiotensin converting enzyme (ACE) has two cleave pathways for the peptide Substance P (SP). Along one arm, the first cleavage generates SP 1-8 and the tripeptide Gly-Leu-Met while the second cleavage generates the dipeptides Arg-Pro, Lys-Pro, Gln-Gln, and Phe-Phe and the tripeptide Gly-Leu-Met. The second arm first generates SP 1-9 and the dipeptide Leu-Met while the second cleavage generates SP 1-5 and the dipeptides Gln-Phe, Phe-Gly, and Leu-Met.

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What does the Angiotensin converting enzyme (ACE) degradation of Substance P (SP) template show?

Angiotensin converting enzyme (ACE) has two cleave pathways for the peptide Substance P (SP). Along one arm, the first cleavage generates SP 1-8 and the tripeptide Gly-Leu-Met while the second cleavage generates the dipeptides Arg-Pro, Lys-Pro, Gln-Gln, and Phe-Phe and the tripeptide Gly-Leu-Met. The second arm first generates SP 1-9 and the dipeptide Leu-Met while the second cleavage generates SP 1-5 and the dipeptides Gln-Phe, Phe-Gly, and Leu-Met.

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