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Anti-inflammatory mechanism of hydrocortisone
Creator
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Description
Anti-inflammatory effects due to decreased proinflammatory cytokines: IL-1, IL-6, TNF-α; decreased macrophage and T-cell activity; decreased expression of adhesion molecules, which decreases leukocyte migration; decreased phospholipase A2, which decreases arachidonic acid and decreases prostaglandins and leukotrienes; decreased nitric oxide production; increased lipocortin-1 production
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