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Antibacterial mechanism of Ag+ ions on Gram-negative bacteria
Creator
s
Description
The Ag+ bind to sulfhydryl(thiol) groups in amino acids and inactivate enzymes or proteins, leading to cell death. Ag+ inactivates enzymes responsible for peptidoglycan synthesis, which prevents cell duplication. Further, the release of iron from organic molecules damaged by Ag+, causes the subsequent formation of reactive oxygen species, leading to protein, enzyme, or DNA disruption and cell death. The Ag+ tend to accumulate in periplasmatic space, leading to protein and enzyme inactivation.
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