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BioRender Template
ASCL1 Overexpression in Small Cell Lung Cancer (SCLC)
Description
This template shows a side-by-side comparison of a normal cell, where DLL3-mediated Notch degradation maintains normal Notch-1 signaling, and a small cell lung cancer cell, where ASCL1 overexpression drives increased DLL3 production. This leads to increased receptor internalization and lysosomal degradation of Notch-1, resulting in decreased Notch signaling.
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