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Avesicular Entosis

Tate Mellor
3+
Creator
s
An editable high resolution scientific image depicting Avesicular Entosis

Description

An endocytosis process, allowing the infiltration of autoreactive CD8+ T cells into BEC which are lining the bile duct. CD8+ T cell undergoes actin remodelling which protrudes out and migrates towards BEC. The invasion of CD8+ T cells requires actomyosin contractile activity, as well as E-cadherin-β-catenin interactions. The T cell stays active inside the BEC, showing a larger and more eccentric state while not being surrounded by a secondary vesicle. Some internalised T cells may be released.
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