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BCR Downstream Signaling
Description
This template shows B-cell receptor downstream signaling in three steps, beginning with antigen-induced cross-linking of the BCR that activates Src family kinases, followed by tyrosine phosphorylation events involving Syk, PLCgamma1, SLP-65, Btk, and Grb2/SOS. These events lead to translocation of the transcription factors NFAT, NF-kB, and AP-1 into the nucleus.
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