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BioRender Template
Biliary Tract Cancers Mechanism and Therapies
Description
This template maps targeted therapies for biliary tract cancers onto the FGFR2, HER2, EGFR, VEGFR, and ROS receptor pathways as well as the mitochondrial IDH1/IDH2 metabolic pathway. Downstream signaling through PI3K/Akt/mTORC1 and RAS/RAF/MEK/ERK is shown alongside specific inhibitors such as pemigatinib, trastuzumab, dabrafenib, ivosidenib, and enasidenib, plus PARP inhibitors acting on BAP1 or other DNA damage repair deficiencies.
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