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BioRender Template
Biliary Tract Cancers Molecular Cascades
Description
This template shows five receptor tyrosine kinases (FGFR2, HER2, EGFR, VEGFR, ROS) at the cell membrane converging on the PI3K/Akt/mTORC1 and RAS/Raf/MEK/ERK signaling cascades in biliary tract cancer cells. It also traces the citrate to alpha-ketoglutarate pathway in the cytoplasm and mitochondria, showing how IDH1 and IDH2 mutations produce D-2HG, which along with the kinase pathways can lead to BAP1 mutations and other DNA damage response deficiencies.
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