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Blockade of CTLA-4 or PD-1 Signaling in Tumor Immunotherapy
Description
This template shows how blockade of CTLA-4 or PD-1 signaling enhances tumor immunotherapy across the priming phase in the lymph node and the effector phase in peripheral tissue. Insets show dendritic cells activating naive T cells via MHC-TCR and B7-CD28 interactions with CTLA-4 blocked, and activated T cells attacking tumor cells via TCR-MHC interactions with PD-1/PD-L1 signaling blocked.
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