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Botulinum Toxin A Effect in Neuromuscular Junction

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Jamerson Silva

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Description: Botulinum toxin A, produced by anaerobic bacteria Clostridium botulinum, blocks the release of acetylcholine from the axon terminal. The botulinum toxin cleaves specific soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins that are essential for binding and fusion of the synaptic vesicles with the presynaptic membrane.

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Botulinum toxin A, produced by anaerobic bacteria Clostridium botulinum, blocks the release of acetylcholine from the axon terminal. The botulinum toxin cleaves specific soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins that are essential for binding and fusion of the synaptic vesicles with the presynaptic membrane.

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