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BRAF Positive Metastatic Melanoma Resistance Mechanism
Description
This template compares the normal MAPK signaling pathway with the mechanism of resistance in BRAF positive metastatic melanoma, listing eight resistance mechanisms including RTK upregulation, loss of NF1, BRAF amplification, BRAF alternative splicing, COT overexpression, ERK activation, loss of PTEN, and activation of alternative pathways. The resistant pathway shows parallel signaling through RAS/RAF/MEK/ERK and PI3K/AKT/mTOR with additional NF-kB and STAT signaling, all converging on cell growth, proliferation, and survival.
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