Breast Cancer to Brain Metastasis

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The development of metastases distant from the primary tumor requires the performance of a long series of events. Breast cancer cells must first detach themselves from the primary tumor, then enter the circulation (intravasation), and travel through the body by following the blood vessels. They then have to get out of these vessels (extravasation) and colonize a new organ (brain) where they multiply and eventually develop into secondary tumors (metastases).