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Calcium Homeostasis in a Mammalian Cell

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Rana Abdelgawad

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Description: Calcium homeostasis is tightly regulated by a network of mechanisms. Receptor operated and voltage-gated Ca channels, facilitate Ca entry, while Na-Ca exchanger and plasma membrane Ca ATPase regulate Ca efflux. Inside the cell Ca is sequestered into sarcoplasmic/ER by SERCA pump. Intracellular Ca release is mediated by inositol triphosphate and ryanodine receptors. This system maintains Ca levels within a narrow range, crucial for cellular functions and signaling.

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Calcium homeostasis is tightly regulated by a network of mechanisms. Receptor operated and voltage-gated Ca channels, facilitate Ca entry, while Na-Ca exchanger and plasma membrane Ca ATPase regulate Ca efflux. Inside the cell Ca is sequestered into sarcoplasmic/ER by SERCA pump. Intracellular Ca release is mediated by inositol triphosphate and ryanodine receptors. This system maintains Ca levels within a narrow range, crucial for cellular functions and signaling.

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