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BioRender Template
CAR-T constructed generations
Creator
s
Description
CAR-T cells design has advanced to reduce toxicity and enhance specific activation. The First-generation CAR-T cells featured a single signaling domain (CD3ζ), essential for initiating T cell activation. Second-gen. introduced a costimulatory domain (CD28 or 4-1BB) to improved T cell proliferation, persistence, and antitumor activity. Third-gen. incorporated 2 costimulatory domains to boost activation and T-cells expansion. Fourth-gen. release cytokines upon activation enhancing immune response.
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