BioRender Template
CAR-T constructed generations
Use This Template – Free
No credit card required to sign up.
This template is fully editable in BioRender
- Swap in different text, shapes, & icons
- Recolor and rearrange every icon, line, & label
- Export or share for any use case
Join 4M+ scientists already making publication-ready figures
Description:
CAR-T cells design has advanced to reduce toxicity and enhance specific activation. The First-generation CAR-T cells featured a single signaling domain (CD3ζ), essential for initiating T cell activation. Second-gen. introduced a costimulatory domain (CD28 or 4-1BB) to improved T cell proliferation, persistence, and antitumor activity. Third-gen. incorporated 2 costimulatory domains to boost activation and T-cells expansion. Fourth-gen. release cytokines upon activation enhancing immune response.
Updated
August 2026
BioRender icons and templates meet journal, grant, and copyright standards. For AI-generated figures, policies vary. Learn More
Not quite the right template? Discover more.
Search thousands of templates across 30+ life-science fields.
Popular topics:
Cell
Cancer
Drug Delivery
Mechanism of Action
Pathway
Try a synonym, or sign up to suggest a template from the app.
Newest templates
BioRender Template FAQs
CAR-T cells design has advanced to reduce toxicity and enhance specific activation. The First-generation CAR-T cells featured a single signaling domain (CD3ζ), essential for initiating T cell activation. Second-gen. introduced a costimulatory domain (CD28 or 4-1BB) to improved T cell proliferation, persistence, and antitumor activity. Third-gen. incorporated 2 costimulatory domains to boost activation and T-cells expansion. Fourth-gen. release cytokines upon activation enhancing immune response.