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CD4 Mimetic-Induced HIV-1 Env Conformational Changes

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Andrés Finzi, PhD

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Description: CD4-mimetic (CD4mc) trigger sequential Env opening on infected cells, exposing ADCC epitopes. This response requires co-receptor binding site antibodies from HIV+ sera, which uncover anti-cluster A epitopes upon CD4mc treatment. Understanding these conformational changes may guide new HIV-1 therapeutic strategies.

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CD4-mimetic (CD4mc) trigger sequential Env opening on infected cells, exposing ADCC epitopes. This response requires co-receptor binding site antibodies from HIV+ sera, which uncover anti-cluster A epitopes upon CD4mc treatment. Understanding these conformational changes may guide new HIV-1 therapeutic strategies.

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