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BioRender Template
CD95/CD95L-mediated signaling pathways
Creator
s
Description
(Left) Binding of m-CD95L to CD95 induces an apoptotic signaling pathway. (Right) m-CD95L processing by proteases leads to the release of different s-CD95L in the extracellular environment. Depending on the ratio m-CD95L/s-CD95L, and the shedding sequence, several signaling pathways can be triggered: cell survival, migration (metastases), chemoattraction & proinflammatory signal, or cell death. Blocking of CD95L binding to CD95 by APG101 blocks both apoptotic & non-apoptotic signaling pathways.
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