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BioRender Template
Cellular Backpacks for Macrophage Immunotherapy
Creator
s
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
This figure describes how cellular backpacks are assembled in 4 layers: 1) A PLGA layer serves as structural support, 2) a PVA encapsulation reservoir is loaded with IFN-γ to preserve M1 macrophage phenotype, 3) a second PLGA layer for the system integrity, and 4) a cell-adhesive layer-by-layer component is created out of PAH and HA-Ald in order to keep the backpack attached to macrophages. Injectable M1 macrophages with cellular backpacks created anti-tumor effects in a murine breast cancer model
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