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Cellular Therapy for Degenerative Retinopathies

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Dr Esther Pomares

•

BioRender Team

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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Degenerative retinopathies show progressive loss of retinal cells. To stop this process, a patient’s skin sample is cultured and fibroblasts are reprogrammed with Yamanaka Factors into induced Pluripotent Stem Cells (iPSC). Genetic analysis allows for guide RNAs generation that will target the mutated gene for correction using CRISPR-Cas9. Treated iPSC are differentiated to retinal pigmented epithelia (RPE) or photoreceptors and injected into the subretinal space, where they will settle.

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What does the Cellular Therapy for Degenerative Retinopathies template show?

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Degenerative retinopathies show progressive loss of retinal cells. To stop this process, a patient’s skin sample is cultured and fibroblasts are reprogrammed with Yamanaka Factors into induced Pluripotent Stem Cells (iPSC). Genetic analysis allows for guide RNAs generation that will target the mutated gene for correction using CRISPR-Cas9. Treated iPSC are differentiated to retinal pigmented epithelia (RPE) or photoreceptors and injected into the subretinal space, where they will settle.

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