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BioRender Template
cGAS-STING signalling pathway
Creator
s
Description
The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is one of many signalling mechanisms of the innate immune system. Its role is to detect dsDNA in the cytoplasm and initiate a response. This simplified diagram shows the activation and downstream effects of cGAS-STING, particularly the upregulation of inflammatory mediators. This pathway is of interest in autoimmunity, cancer, cardiovascular diseases, and intestinal diseases
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