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cGAS-STING signalling pathway

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Rosie Harrison

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Description: The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is one of many signalling mechanisms of the innate immune system. Its role is to detect dsDNA in the cytoplasm and initiate a response. This simplified diagram shows the activation and downstream effects of cGAS-STING, particularly the upregulation of inflammatory mediators. This pathway is of interest in autoimmunity, cancer, cardiovascular diseases, and intestinal diseases

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What does the cGAS-STING signalling pathway template show?

The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is one of many signalling mechanisms of the innate immune system. Its role is to detect dsDNA in the cytoplasm and initiate a response. This simplified diagram shows the activation and downstream effects of cGAS-STING, particularly the upregulation of inflammatory mediators. This pathway is of interest in autoimmunity, cancer, cardiovascular diseases, and intestinal diseases

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