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BioRender Template
Chemerin Synthesis and Signaling Cascade
Description
This template shows chemerin signaling starting from retinoic acid uptake by adipocytes via STRA6 and RAR/RXR-driven transcription of the RARRES2 gene, which produces chemerin. Secreted chemerin acts on target cell receptors CMKLR1, GPR1, and CCRL2 to activate PI3K/AKT, ERK1/2, and NF-kB signaling, along with calcium influx, leading to changes in target gene expression.
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