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Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection
Creator
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Description
Chronic HIV infection leads to T cells metabolic stress, immune activation and T cell dysfunction. Despite ART, HIV infection induces persistent immune activation and metabolic alterations in T cells, marked by increased Type I IFN, heightened Reactive Oxygen Species (ROS), mitochondrial dysfunction, etc. Both persistent immune activation and metabolic stress eventually contribute to T cell exhaustion.
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