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Classification and common cancer-associated genomic aberrations in breast cancer.
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Description
(A) Genomic aberrations in cancer cells may be inherited (i.e., germline alterations) or somatically acquired (i.e., obtained any time after fertilization). Such alterations may include small, DNA-level alterations, such as INDELs and single nucleotide substitutions (shown left) and larger, chromosome-level alterations (shown right). (B) Frequencies of chromosome arm aneuploidies, including gains (red) and losses (blue) in the breast cancers from The Cancer Genome Atlas breast cancer cohort.
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