BioRender Template

CMGH 2

Created by

Daniel Rodriguez

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Description:

This template compares VLDL secretion in wild-type versus StarD5 knockout hepatocytes, showing how StarD5 normally shuttles cholesterol to the ER and Golgi to support nascent VLDL formation and its secretion. In the StarD5-knockout cell, reduced cholesterol transport and nascent VLDL lead to oxysterol-induced mitochondrial toxicity, increased triglyceride synthesis and lipid droplet storage, and SREBP1/TAZ-driven expression of fibrosis-promoting genes.

Updated

August 2026

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