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BioRender Template
Contemporary understanding of Orthopoxvirus infections in the human CNS.
Creator
s
Description
Neuroinvasion may occur by infected leukocytes trafficking across the BBB or by direct infection via brain endothelia. Astrocytes are most permissive to infection by MPXV, resulting in inflammatory cell death, termed pyroptosis, which may contribute to neurovirulence through cleavage of gasdermin B (GSDMB) and ensuing cell lysis with adjacent neuronal damage. To date the cell tropism and mechanisms of neurovirulence for other Orthopoxviruses remains unknown
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