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BioRender Template
Convergence of VEGF and YAP/TAZ Signaling Pathways
Description
This template shows how VEGF signaling through VEGFR2 and neuropilin/integrin receptors activates two parallel cascades, Src-Rho-actomyosin and FAK-Rac-PAK-Merlin, that converge to inhibit LATS kinase. This releases YAP/TAZ to bind TEAD in the nucleus, driving gene transcription that promotes cytoskeletal remodeling, angiogenesis, and self renewal.
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