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BioRender Template
CRISPR-Cas9 Adaptive Immune System of Streptococcus pyogenes Against Bacteriophages
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The CRISPR-Cas9 system confers bacteria with adaptive immunity against invading bacteriophages. Once infected, Cas1 and Cas2 incorporate a short segment of viral genome as spacers within the CRISPR locus of the bacterial genome. Upon reinfection with the same bacteriophage, the CRISPR locus is expressed as pre-CRNA, along with tracrRNA. This pre-crRNA is processed to yield guide RNAs (gRNAs) which bind the ribonucleoprotein, Cas9 as well as complementary segments of the invading virus genome, prompting its cleavage by Cas9.
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