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BioRender Template
CRISPR Technology: Epigenome Editing
Description
This template shows CRISPR-based epigenome editing using a dCas9 fusion protein with an effector domain that is guided to a specific DNA sequence near existing epigenetic modifications on nucleosomes. Before editing, the modifications keep the downstream locus repressed, while after epigenetic editing by the dCas9-effector complex, the modifications are removed and the locus becomes activated.
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