BioRender Template

Cyclosporine A (CsA) Mechanism of Action

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Nick Delrose

•

BioRender Team

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Description: This template shows how cyclosporine A blocks T cell activation by binding FKBP and inhibiting calcineurin, preventing dephosphorylation of NFATc and its translocation into the nucleus. Without dephosphorylated NFATc, cytokine gene transcription and release of IL-1, IL-3, IL-4, TNF-alpha, and IFN-gamma are blocked, reducing bone erosion and cartilage damage.

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What does the Cyclosporine A (CsA) Mechanism of Action template show?

This template shows how cyclosporine A blocks T cell activation by binding FKBP and inhibiting calcineurin, preventing dephosphorylation of NFATc and its translocation into the nucleus. Without dephosphorylated NFATc, cytokine gene transcription and release of IL-1, IL-3, IL-4, TNF-alpha, and IFN-gamma are blocked, reducing bone erosion and cartilage damage.

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